Crow’s feet and smile lines are among the most common concerns patients bring to us at The Dermatology, Laser & Vein Center in Cincinnati. These expressive wrinkles often appear earlier than other facial lines due to the constant motion of smiling, squinting, and laughing—and they can be tough to treat without sacrificing natural expression.
Enter Daxxify, the first peptide-powered wrinkle relaxer with long-lasting effects. While it’s FDA-approved for frown lines, Daxxify is also used off-label to treat crow’s feet and smile lines around the eyes with precision and impressive results.
In this guide, we’ll explain how Daxxify works for these dynamic wrinkles, what makes it a great option for delicate areas, and what kind of results you can expect.
What Are Crow’s Feet and Smile Lines?
Crow’s feet are the fine lines that radiate outward from the outer corners of the eyes, often becoming more noticeable when you smile or squint.
Smile lines—also called “orbicular lines” or periorbital wrinkles—may appear as short creases next to the eyes or extend downward toward the cheek when smiling.
These lines develop from:
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Repeated facial movement
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Collagen breakdown over time
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Sun exposure
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Skin thinning with age
Because the skin around the eyes is thinner and more delicate than other facial areas, these wrinkles often show up first and become deeper with time.
Can Daxxify Treat Crow’s Feet?
Yes. While Daxxify is officially FDA-approved for glabellar lines (the “11s” between the eyebrows), it is also widely used off-label to treat crow’s feet with great success—just like Botox or Dysport.
Daxxify works by:
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Relaxing the orbicularis oculi muscle around the eye
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Preventing exaggerated creasing during expression
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Softening etched-in lines
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Giving the eye area a smoother, more youthful appearance
With Daxxify, patients typically enjoy longer-lasting results than with traditional neuromodulators—up to 6 to 9 months of wrinkle reduction around the eyes.
What Makes Daxxify Unique for Eye Wrinkles?
The delicate area around the eyes requires a product that is:
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Precise
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Gentle
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Long-lasting
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Stable under repeated expression
Daxxify stands out because:
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It is peptide-stabilized, not albumin-based, making it ideal for patients seeking vegan-friendly options
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It may last twice as long as Botox or Dysport in many patients
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It starts working faster, often in just 1 to 2 days
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It provides a refined, elegant smoothing effect without the frozen look
In the hands of an experienced injector, Daxxify can minimize crow’s feet while preserving the sparkle and warmth of your smile.
How Daxxify Is Used for Crow’s Feet and Smile Lines
At our Cincinnati practice, Daxxify is administered with extreme precision. We use small amounts of product and micro-injections to target the right muscles without over-relaxing them.
Each treatment is:
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Tailored to your facial structure
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Adjusted for symmetry and movement
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Designed to prevent static lines from worsening over time
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Quick—usually 10–15 minutes
The treatment is comfortable, with minimal downtime and no anesthesia required.
When Will You See Results?
Most patients begin seeing improvements in 1 to 2 days after treatment. Full smoothing results appear within 5 to 7 days and may last up to 6 to 9 months, depending on your muscle activity and individual metabolism.
Patients often report:
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Softer crow’s feet when smiling or squinting
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A more youthful eye area
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Smoother transitions from the lower eyelid to the cheek
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A refreshed and less tired appearance
Who Is a Good Candidate?
Daxxify is ideal for:
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Adults experiencing moderate to severe crow’s feet or smile lines
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Patients who’ve previously used Botox or Dysport but want longer-lasting results
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First-time injectable patients who want natural results
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Individuals looking for a non-surgical option to rejuvenate the eye area
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Those who prefer a non-animal, synthetic product
We’ll evaluate your skin, facial movement, and expression goals during your consultation to ensure the best approach.
Is It Safe Around the Eyes?
Yes—when performed by an experienced, medically trained injector. At The Dermatology, Laser & Vein Center, we have extensive experience using neuromodulators around the eyes and follow precise dosing protocols to ensure safety and aesthetic balance.
Side effects are rare but may include:
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Mild swelling or redness at the injection site
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Bruising (temporary)
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Rare risk of eyelid heaviness (temporary and correctable)
We prioritize safety, comfort, and conservative dosing, especially for sensitive areas like the eyes.
How Long Do Results Last?
Daxxify’s results typically last:
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Up to 6 months for moderate muscle activity
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Up to 9 months for patients with mild dynamic movement
This extended duration sets it apart from other wrinkle relaxers and offers a significant convenience for busy patients.
You may only need 2 treatments per year, compared to 3 or 4 with other products.
Benefits of Daxxify for Crow’s Feet
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Longer-lasting results (up to 9 months)
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Fewer injections per year
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Natural facial movement is preserved
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Faster onset than Botox
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Ideal for wrinkle prevention as well as correction
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Excellent for men and women of all ages
Why Patients in Cincinnati Choose Our Practice
When it comes to treating crow’s feet and smile lines, injection technique and experience are everything. At The Dermatology, Laser & Vein Center, we specialize in advanced injectable treatments and were among the first in Cincinnati to offer Daxxify.
Why patients trust us:
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Decades of experience in aesthetic medicine
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Customized treatment plans for each face
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Mastery of facial anatomy and symmetry
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Gentle touch and natural-looking outcomes
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Full range of wrinkle-relaxers to choose from
Whether it’s your first time trying injectables or you’re switching from Botox, we’ll guide you through every step.
Frequently Asked Questions
Can Daxxify be used to treat crow’s feet?
Yes. Although FDA-approved for frown lines, Daxxify is commonly used off-label to treat crow’s feet around the eyes.
Is Daxxify safe for the eye area?
Yes. When administered by a trained professional, it’s very safe and effective for treating fine lines near the eyes.
How long does it last around the eyes?
Most patients enjoy results for 6 to 9 months, depending on the area and muscle movement.
Does it freeze your expression?
No. We use conservative dosing and advanced techniques to preserve natural facial movement while softening lines.
When will I see results?
Many patients see improvement in 1 to 2 days, with full results in about a week.
Is there any downtime?
No. You can return to your normal routine right away.
Smooth Your Smile Lines with Confidence
If you’re tired of crow’s feet and smile lines but want a treatment that’s subtle, long-lasting, and safe, Daxxify may be the perfect fit. At The Dermatology, Laser & Vein Center in Cincinnati, we’ll help you refresh your eye area without changing your natural expression—just a smoother, more confident version of you.
Schedule your consultation today and experience the next evolution in wrinkle treatment.
